Implementation
STEM CELLS IN DEVELOPMENT AND DISEASE
- Theme 1: Signaling pathways
- Theme 2: Gene regulation/epigenetics
- Theme 3: Stem cells and lineage differentiation
Work Packages (WP)
- 1. Rapid screening for developmental pathways
(Meijlink, Deschamps, Grootegoed, Clevers, Fodde)
Themes: 1, 3
- 2. Downstream targets of Wnt signalling: molecules for cancer intervention
(Clevers, Fodde)
Themes: 1, 3
- 3. Signaling centres in embryonic pattern formation and organogenesis
(Grootegoed, Deschamps, Meijlink, Meijer)
Theme: 1
- 4. Development of rapid assays to score developmental mutants
(Grosveld, Minos Biosystems )
Themes: 1, 2, 3
- 5. Identification and characterization of in vivo interacting signaling molecules and transcription factors by biotin tagging
(Meijer, Grosveld)
Themes: 1, 2
- 6. Generation of single chain antibodies to signaling molecules, transcription factors and chromatin modulators of stem and differentiated cells
(Meijer, Grosveld, Dzierzak, Mummery, van Lohuizen, Verrijzer)
Themes: 1, 2, 3
- 7. Identification of stem cell versus differentiated cell genetic programs
(Dzierzak, Mummery, Fodde, Clevers, Miejlink)
Theme: 3
- 8. Signal mechanisms required for complete differentiation of ES cells to desired cell lineages
(Mummery, Dzierzak, Embryonic Stem Cells International, PamGene BV)
Theme: 3
- 9. Epigenetic transcriptional control in stem cells by master developmental regulators, PcG and TrxG
(van Lohuizen, Verrijzer, Mummery)
Theme: 2
- 10. Role of SWI/SNF complexes in the control of cell proliferation and disease
(Verrijzer, Grosveld, Dzierzak)
Theme: 2
MilestonesClick to open: "Time table and measureable miletones of each workpackage"
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